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Is Appethyl Safe? Review of Clinical Trials and Side Effects

Appethyl – Do Clinical Trials Show it to be Effective?

Appethyl was used in 7 clinical trials during 2013, each showing weight and hunger control benefits while not exhibiting any negative side effects.

We encourage you to read the full review of Appethyl on the homepage which has purchase information at the beginning and end of the article.

During 2013, 5 human trials and 2 animal trials were conducted. The patented technology and product for these trials are from Lund University in Stockholm Sweden.

Results from 5 Human Trials of Appethyl

  1. Appetite was significant reduced for 4-6 hours after taking Appethyl with a meal. The 3.7 g and 7.4 g dosages resulted in the same hunger reductions. As well, subjects experienced a reduction in even thinking about food.
  2. Cravings for sweets specifically were also reduced after the first dose. However, this increased even more over 3 months of using the product.
  3. Weight loss and fat loss was substantially higher in the control group than in placebo groups.
  4. After even just one dose, subjects experienced a sustained decrease in appetite over 3 to 4 days.

One trial, 48 overweight women all lost weight and did not experienced cravings for sweets in between meals. This desire for sweets decreased even more than the overall desire for any food.  This holds tremendous hope for many dieters.

Two 2013 Animal Trials

Two animal trials were conducted to study the physiological effects of the spinach extract. The first was using 10 rats to study the effect on the gut flora (good bacteria in the intestines). The rats were fed Apethyl for the 10 days had a significant increase in beneficial probiotics, showing the periodic benefit of the product. As well, the rats had a reduction in hunger, ate less, and had a lower insulin level.

The second trial used Pigs, to study glocuse levels and CCK hormones. Within the first hour, the CCK hormones increased to send satisfied signals to the brain and blood glucose levels were lower. [1]

2014 Appethyl Studies

The studies from 2013 showed that thylakoids did slow down fat digestion and produced satiety hormones such as CCK.  In this next study, they want to confirm if the intestinal hormone GLP-1 was also released and if the normal hunger urge was affected.

They also found the prebiotic effects were also noted in the trials.

Data on this study was published in Appetite and involved 38 overweight women between the ages of 40 and 65 and lasted for 12 weeks. Appethyl or a placebo were taken before breakfast over the 12 weeks.

Those taking Appethyl lost an average of 5kg (11 lbs) during the study, 43% greater body weight loss than the placebo group.  Exercise and other factors were required of all study participants as well.

Lund University researchers proposed that the thylakoids (green leaf membranes) slow down the digestion process and allow the proper hormones to be sent to the brain signifying a sensation of being full – satiety hormones.

Charlotte Erlansons-Albertsson, author of the study and Professor of Medicine and Physiological Chemistry at the Lund University, stated that their research is all about using the time it takes to digest food to hep the body produce more of the hormones that tell our brains that we are full and satisfied. This means that people are better able to eat the foods they should and reduce the cravings for the sweets and snacks.

2014 Results:

The Appethyl group lost an average of 43% more weight over the placebo group.  LDL cholesterol also decreased a significant amount.

They also discovered that the thylakoids increased the release of GLP-1 hormone, the satiety hormone.  Very significantly, the urge to eat sweets and chocolate which is a measure of hedonic hunger, decreased substantially.  The hedonic hunger decreased even more over the first week.

Body fat, waist measurements and leptin levels all decreased as well. [2]



Personal Experience with the Product

I have personally tired the product although I do not personally have hunger issues to deal with.  The taste was mild, but much like spinach.  I did add cinnamon one day and some peppermint extract on another and that did remove some of the taste if it is too strong for you.  I did find it reduced hunger sensations a bit for me as well.  Even though I normally do not have issues with it.  One day I felt very full, like I had eaten a moderately large Thanksgiving Day meal.  For 5 hours I felt full.


I have three friends who have taken it regularly for a few months and they all had positive results.  Two more than the others, but one lost well over 20 pounds over a few months.  He looks much better now.



[2]. Appetite, “Body weight loss, reduced urge for palatable food and increased release of GLP-1 through daily supplementation with green-leaf membranes for three months in overweight women”

authors: Caroline Montelius, Daniel Erlandsson, Egzona Vitija, Eva-Lena Stenblom, Emil Egecioglu, Charlotte Erlanson-Albertsson


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